Which statement is true about AFP testing in this context?

Which statement is true about AFP testing in this context?

• A. It has potential for false positives or false negatives
• B. It is 100% accurate
• C. It cannot predict anything
• D. It is only for chromosomal abnormalities

Answer: (A)

AFP testing is a screening tool, not a definitive test, so its results reflect risk rather than certainty. Because many factors can influence AFP levels, a high AFP may point to an open neural tube defect but can also occur with dating errors, multiple gestations, or other benign reasons. Likewise, some affected pregnancies may have normal AFP levels, leading to a false negative. This variability is why the statement that AFP testing has potential for false positives or false negatives is the best choice. Confirmatory steps like detailed ultrasound or diagnostic tests on amniotic fluid are used when screening results raise concern.